Release date: 2016-07-04 Image taken from: webeye.ophth.uiowa.edu -- In a recent study published in the international journal Nature , scientists from the Osaka University School of Medicine developed a 2D culture system that promotes human induced pluripotent stem cells (iPS cells). Spontaneous differentiation to simulate the development of the entire eye. In past studies, researchers have only described a special technique that can produce the posterior part of the eye, the retina, retinal pigment epithelial cells, etc.; and the new technique developed by the researchers in this paper can simultaneously produce the anterior part of the eye (the stratum corneum and The lens and so on (the retina and retinal pigment epithelial cells, etc.), and this study found the world's first. Severe corneal epithelial disease often leads to blindness. Scientists often use the donor's cornea to perform corneal transplantation on patients. However, this therapy is often blocked due to lack of donors and rejection, and patients may face treatment. A variety of obstacles. In the past, scientists have not developed new techniques to induce human iPS cells to differentiate into corneal epithelial cells and ex vivo cells to create functional corneal epithelial tissue. In this study, a novel culture system developed by researchers can use human iPS cells to create a 2-dimensional structure that is a spontaneously formed ectodermal multiple region (SEAM) that includes concentric regions of four cells. Most of the population cells that make up the eye during development are formed at specific locations in SEAM, such as corneal epithelial cells, retinal cells, and epithelial cells of the lens. In this study, the researchers successfully isolated corneal epithelial progenitor cells from the third region of SEAM, thus successfully producing functional corneal epithelial tissue. At the same time, the researchers confirmed the therapeutic efficacy of corneal epithelial tissue formed by human iPS cells by transplanting them into animal models. Related findings may help scientists use human iPS cells to reconstruct corneal epithelial tissue in the eye, while late SEAM may potentially advance the development of new technologies to reconstruct corneal tissue and other parts of the eye for effective treatment of ocular diseases. The patient may be a big benefit. Source: Bio Valley Vital Signs Monitor,Pulse Oximeter,Oxygen Concentrator,Patient Monitor,valve inflatable extension tube Anesthesia Medical Co., Ltd. , https://www.jssinoanesthesias.com
Nature: A major breakthrough! Scientists use human iPS cells to reconstruct ocular corneal tissue function