Pharmacological effects 1. Effects on Cardiovascular System Infusions, tinctures, and decoctions of ground bone used in anaesthetized dogs, cats, and rabbits have significant antihypertensive effect, and are accompanied by reduced heart rate and rapid breathing. Stomach also has a significant antihypertensive effect. The injection of 0.375g/kg intravenously into the anesthetized dog can cause the blood pressure to drop to zero and die. The low-dose repeated injection did not show rapid tolerance. Dioscorea bulbar ethanol extract was given to rats intravenously 0.5g (crude drug)/kg also had significant antihypertensive activity. During hypothermia, the ECG showed that the heart rate was slowed, the PR interval was prolonged, and the T wave was reduced. The dose of poisoning can cause the guinea pig heart to produce partial or complete block of atrioventricular conduction. In addition to central involvement, the antihypertensive effect of Digupi may also be related to its role in blocking sympathetic nerve endings and direct vasodilation. In addition, Alizarin A and Alizarin B have the effects of anti-corticoids and renin, and are also one of the mechanisms of antihypertensive effect. 2. Hypoglycemic and hypolipidemic effects were given to the rabbits to administer the decoction of bone decoction. The blood glucose was increased for a short period of time and then decreased for a long time. It had not recovered after 4-8 hours. There is no obvious antagonistic effect on the hyperglycemia caused by the injection of epinephrine, but it can shorten the duration of hyperglycemia. Rabbit subcutaneous injection of Digupi extract can also reduce blood glucose. The decoction of Digupi Decoction has a certain palliative effect on the morphological damage of pancreatic islet B cells in alloxan-induced diabetic mice. Distillation of ground bone extract can decrease the serum total cholesterol in experimental rabbits, but it has little effect on triglyceride content, and it has no significant effect on liver fat content. Betaine has anti-fatty liver effect. 3. The anti-pathogenic microbial decoction decoction has strong inhibitory effects on typhoid bacilli, paratyphoid A, and dysentery fleurii, but it has no effect on Staphylococcus aureus; -1 virus strain inhibits its cytopathic effect; against Mycobacterium tuberculosis is a low-effective antibacterial drug. 4. Antipyretic effects of bone water extracts, ethanol extracts and ethyl ether residue aqueous extract or injection of artificial fever rabbits have a significant antipyretic effect. The ether extract and the water extract of the residue after ethanol extraction have no effect. Its antipyretic effect is weaker than aminopyrine, about equal to other antipyretics. 5. Other effects of decoction of bone skin have inhibitory effect on interleukin-2 production in spleen cells of normal mice, and significantly enhance the decrease of interleukin-2 production in mouse splenocytes induced by cyclophosphamide; Azathioprine induced abnormal interleukin-2 production. Dipisone injection (100%) has a significant excitatory effect on isolated uterus in non-pregnant rats and mice.
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The pharmacological effects of Digupi