Only one thousand pieces of future gene sequencing!

Only one thousand pieces of future gene sequencing!

Produced by: China Science Expo SELF Gezhi Road Forum

With the change of history, the causes of human unnatural death are also constantly changing: before 1900, mainly hunger and war; from 1901 to 1950, it was mainly infectious diseases; from 1951 to now, the main change For cardiovascular and cerebrovascular diseases, cancer; scientists predict that in the future, nervous system diseases will become the most important cause of human unnatural death... With this development process, human medical level is also constantly developing and innovation, then based on the precision of genome research What role will the medical future play? Dr. Chen Ke from the Beijing Genomics Institute of the Chinese Academy of Sciences gave us an answer in the SELF forum.

There are often people who say that Chen Ke looks like your father. Some people say, Chen Ke, you are a little more like your mother. Then why is this? People who have studied biology know that because our DNA, which is the base, is half from Dad and half from Mom. There is no doubt that our appearance is the embodiment of their combination. In fact, not only in appearance, our height, our fat and thin, and whether we are susceptible to certain diseases, are closely related to our genes.

Let's take a look at a photo of people. I think most people are not strange to him, yes, he is Beckham. He is composed of 1 × 10 ^ 14 cells in terms of our genomics. Each cell consists of three major parts: the cell membrane, the cytoplasm and the nucleus, from the outside to the inside.

The so-called nucleus, as the name suggests, is the core, the most important component of cells, and the cells are the basic units that make up every organism in the world of life. So what is the state of the cell's nucleus going down? This is what Mr. Li Geng has just said. In 1953, humans discovered the DNA double helix structure. So from large to small, from the nucleus, chromosomes, to DNA. DNA is the most basic unit, we call it base, it has four types of ATGC. In other words, we are made up of these four structures of DNA. 3.2 × 10 ^ 9 base pairs, this is the number of DNA in our human genome.

Just from macro to micro, from Beckham to base DNA to observe; then look at what is the process? The first is four kinds of DNA. The most basic component is ATGC, they form a certain sequence. Further up, the functional sequence we call the gene, the gene and the protein contained in the periphery of the gene, we call it the genome; genome composition The nucleus, the main component of the cell, the cell goes up, forms an organ, forms a system; for example, our respiratory system, blood system, digestive system; finally, Beckham is assembled, this is from microscopic Macro process.

Where is the wonder of this process? For example, everyone may ask what is the gene and what is the role? There is such a so-called "central rule" in our biology textbooks, starting with bases or DNA, to RNA, to proteins, and the ultimate goal of this process is to form proteins. The smile of the child, the eyebrows between the couples, I am here to speak, you listen below, all the movements are our protein performing functions.

DNA is so important. It is called the source code of our lives. This source code gives us all the activities that can be traced back to DNA, so we can find the cause of a problem from DNA to explain it.

It is because of the importance of the genome that human scientists have begun to unite for research. In the 1990s, specifically in 1990, scientists in the field of genetics, led by the United States and the United Kingdom, joined forces to launch the Human Genome Project, abbreviated as HGP, composed of scientists from six countries.

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