Release date: 2016-07-04 Cell biologists from the Southwestern Medical Center recently found a new way to determine telomere length, which will have an impact on cancer progression and aging research. Broadly speaking, telomeres can help determine if cells are accurately replicated. As cell division telomeres gradually degrade and become shorter, causing cell senescence, studies have suggested that telomere degradation may have some effect on human aging. Scientists at the Southwest Medical Center hope to use the knowledge of telomeres to delay or prevent cell senescence, and possibly help control cancer cell growth through cancer cell telomeres. Finding the best and most sensitive telomere measurement method is an important step in helping scientists finally find ways to promote healthy cell growth and limit or prevent cancer cell growth. The telomere is located at the end of the chromosome. As the cell divides, the telomere can help maintain the stability of the genetic information carried by the chromosome and prevent chromosome fusion. But telomeres will become shorter and shorter, eventually triggering DNA damage along with other factors leading to aging progression and increasing the risk of cancer. Scientists are interested in understanding the process of cell senescence to create "immortal cells." If new cells that do not undergo telomere degradation are available, they will be important for the treatment of aging-related diseases. In contrast, if you can control the cell aging process, it is possible to promote cancer cell death: by promoting the shortening of telomeres in cancer cells, it can prevent the cancer cells from indefinitely dividing and proliferating in the early stage of cancer, delaying or preventing cancer progression. If the tumor has formed, anti-telomere therapy may prevent cancer from recurring. In order to achieve these ideas, the first step is to develop a method for accurately measuring the telomere length. Radioactive probes, often used for telomere length measurements, are generally less stable, require long exposure times, require hazardous radioactive material handling, and present other potential safety issues. Another popular non-radioactive method, the DIG (digoxigenin) probe, requires relatively more genomic DNA and is less sensitive. The new non-radioactive method developed by the researchers uses multiple DIG molecules to increase sensitivity and stability of telomere detection, and is a new and effective method for detecting telomere length. "Probes generated using this new method can significantly enhance the sensitivity of telomere length measurements," explains cell biology professor Jerry Shay. This study provides a basis for the future development of telomere-based anti-aging and anti-cancer methods. Source: Bio Valley Biological Microscope Biological Microscope,Trinocular Thermostat Microscope,Biological Trinocular Microscope,Biological Artificial Microscope NINGBO VANCO INSTRUMENT CO.,LTD , https://www.vancoscope.com
New technology for accurate detection of telomere length for cancer and aging research
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