Zika virus causes congenital malformations and new discoveries

Zika virus causes congenital malformations and new discoveries

Release date: 2016-10-20



Scientists from the University of Florida's Scripps Research Institute (TSRI) recently described the findings of how the virus attacked the brain of newborns in a study that will one day help people eliminate Neonatal congenital malformations caused by the card virus.

The study, led by Associate Professors of the University of Scripps (TSRI), Hyeryun Choe and Damon Page, was recently published in the journal Nature Science.

In this new study, scientists have observed the effects of viruses in two different aspects of animal models—in the early postnatal development, the brain grows rapidly, and when weaned, the brain has largely reached adulthood. the size of.

"An animal model of Zika virus infection showed a large-scale apoptosis (programmed cell death) in some brain regions shortly after birth, but did not show a corresponding phenomenon in older animal models. "Choe said.

This finding expands on current cell types that are susceptible to Zika virus infection, including not only neuronal progenitors, but also neuronal cells in the late stages of mitosis that have completed division, which are rapidly growing at the cell size level. The results of this study are consistent with the theory that the rapid growth phase of the brain is highly susceptible to neurodevelopment by Zika virus.

"The more interesting aspect of this study is that it compares two time points," Page said. "There are neuronal apoptosis in both time points, but when the brain grows rapidly, it is much larger." We can use this powerful effect to detect potential therapeutic effects, and use this effect to explore whether some genetic backgrounds enhance the sensitivity and resilience of Zika virus-induced microcephaly."

In Uganda in 1947, Zika virus was first isolated from rhesus monkeys. It is transmitted by mosquitoes and is closely related to several other human pathogens, including West Nile virus, dengue fever, Japanese encephalitis virus and yellow fever. According to extensive reports, the virus outbreak in Brazil in 2015 coincided with a sharp increase in cases of microcephaly.

"Our research aims to establish a valuable model to discover the mechanisms underlying the congenital malformations of Zika virus infection," said Wen-Chin Huang, a graduate student at the University of Scripps (TSRI), the first in the study. Author.

The team said that it will continue this research and continue to deepen the theory and fight against the virus.
 
Http://medicalxpress.com/news/2016-10-scientists-uncover-facets-zika-related-birth.html

Source: Noble

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