"Leader, please ask for one thing, and ask you not to check again. This medicine is not fake. Can the patient not know it? I have been sick for 3 years, the genuine medicine has been eaten for 3 years, the house has not been eaten, and my family has been me. I have eaten it. Now, this cheap medicine only sells 500. It can save lives. Drug dealers don’t make money at all. Who can still have a patient? Can you guarantee that you will not get sick for a lifetime? I don’t want to die, I want to live, can I? "This is a fascinating line in the current phenomenal movie "I am not a drug god." "Chronic myeloid leukemia", "Gleevec", "Indian drug anticancer drug purchasing", "Lu Yong", "Nova Pharmaceutical" became the hot search words after "I am not a drug god". In the past two days, the doctors and valleys comprehensively reported that "I am not behind the release of the drug god; why the Indian generic drug is so low" has aroused great attention from readers, talking about the generic drug in India, the domestically produced imitation Gleevec How's it going? It is understood that Novartis's Gleevec has entered the Chinese market for more than 10 years, and its patent period has expired on April 1, 2013. Due to huge market potential, many domestic pharmaceutical companies have started to conduct Gleevec. Imitation, at present, there are three enterprises in China that can produce Gleevec generic drugs: Jiangsu Haosen, Zhengda Tianqing, Shiyao Ouyi, among which, Haosen’s Weiwei (trade name) and Zhengda Tianqing 50mg, 100mg of Gnicon (trade name) received the approval number of the original CFDA in 2013, and 100mg of imatinib mesylate tablet from Shiouyi was also approved in 2014. For the efficacy of Gleevec's generics, according to reports, the results of the human bioequivalence test conducted by Zhengda Tianqing on Gnike showed that after a single dose of oral administration of the reagents and reference preparations (Gleevec) The absorption efficiency and the degree of absorption were equivalent, and there was no significant difference in the peak time of plasma imatinib and imatinib metabolites. At the same time, Zhengda Tianqing also conducted clinical follow-up on a number of patients who participated in clinical trials. The longest tracking time was 18 months. The data obtained were not significantly different from the data used in the original drug Gleevec. After the listing of Weiwei, Jiangsu Haosen also conducted a study on the equivalence of health products with the original research drug. The results showed that the pharmacokinetic parameters of Weiwei and Gleevec were similar, and the incidence of adverse events was compared with Gleevec. There is no obvious difference, which is consistent with the health of the grid. In August 2014, Howson also conducted a head-to-head comparison test between Weiwei and Gleevec, which proved the above conclusion again. At the same time, according to the Insight Medical Intelligence Bureau, Jiangsu Haosen rate has received the approval of the drug “imatinib†for the drug supplement application issued by the CFDA, which became the first to pass the consistency evaluation of imatinib. enterprise. Most doctors who have used the domestic Gleevec have also said: "From the evaluation results of patients who use the domestic Gleevec generic drug every three months, the patients are more effective in importing Gleevec with the efficacy and safety of the drug. There is no difference." "The patients who were treated had no significant difference in the efficacy and use of Gleevec after using the domestic generic drugs," which ultimately dispelled the question many doctors had when the Gleevec was just listed. Talk about the efficacy, and then talk about the price that everyone cares most. According to the Insight data of the Lilac Garden, the winning price of Nolin (100mg*60) of Shiyi Ouyi is 901.16 yuan, and the winning bid is 16 areas. Jiangsu The winning bid price of Haosen's Weiwei (100mg*60) is 1159.97 yuan, and the winning bid covers 16 areas. The winning price of Zhengi Tianqing's Gnike (100mg*60) is 872.19 yuan, and the winning bid covers 17 areas. In contrast, Novartis's original Gleevec (100mg*60) won the bid price of 10,500 yuan, and (100mg*120) won the bid price of 23,500 yuan. However, even if the prices are far apart, the current market share of Gleevec is still much higher than that of the domestic Gleevec. According to the 2016 statistics of the relevant statistics, Novartis Gleevec (annual sales of 1.54 billion yuan) The market share is the highest at 80.29%, followed by Jiangsu Weisen's Weiwei (annual sales of 210 million yuan) market share of 10.97%, followed by Zhengda Tianqing's Gnike (annual sales) The market share of 1600 million yuan is 8.53%. Finally, the market share of Nolining of Shijiazhuang Ouyi is only 0.21%. In addition to being more superstitious about the quality of the original drug, there is also a very important factor is medical insurance. In July 2017, 36 drugs were included in the national medical insurance catalogue, half of which were cancer treatment drugs, and Gleevec was one of them. After that, the patient's monthly burden was reduced to about 2,000 yuan. Many provinces and cities have already put Gleevec into health care before. For example, the Sichuan Provincial Department of Human Resources and Social Security issued the "Relationship of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors" in March 2015. The gastrointestinal stromal tumor drug fee is included in the notice of the scope of medical insurance fund payment. The "Notice" clarifies that since March 1 of that year, all participants in Sichuan Province basic medical insurance, urban residents' basic medical insurance and urban and rural co-ordination have been realized. The insured persons of the basic medical insurance for urban and rural residents in the region are included in the scope of payment for the basic medical insurance funds in each of the districts for the treatment of tyrosine kinase inhibitors produced by chronic myeloid leukemia or gastrointestinal stromal tumors. After Gleevec is included in the medical insurance, the insured person pays for the tyrosine kinase inhibitor drug for chronic myeloid leukemia or gastrointestinal stromal tumor, and the basic medical insurance fund pays 75%, paying for each disease. The maximum amount is 60,000 yuan per person per year. For example, Wuxi, where the first person of India’s anti-cancer drug purchase is located, Wuxi, if the patient meets the conditions of an annual income of no more than 120,000, no second suite, no more than 200,000 vehicles, etc., the drug price can enjoy government assistance, ie The drug is bought three to nine, the total price is 72,000 yuan, and the provincial medical insurance is reimbursed 75%. The conversion is less than 20,000 yuan a year. However, some industry insiders said that the imatinib of Jiangsu Haosen passed the unanimous evaluation, and under the double-plus of quality and price, the market volume will show new changes.
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It is time to talk about domestic Gleevec!
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