The chemical formula of enzalutamide is 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thione -1-imidazolidinyl]-2-fluoro-N-methylbenzamide, its clinical drug was jointly developed by Medivation and Astellas, and approved by the US Food and Drug Administration on August 31, 2012 FDA-approved for the treatment of advanced male castration-resistant prostate cancer that has spread or recurred under the trade name Xtandi[1], which is available as an oral preparation. Enzalutamide (MDV 3100) is an androgen receptor antagonist that blocks androgen binding to the androgen receptor and prevents nuclear translocation and coactivator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer. Cas 143782-23-4,Enzalutamide Intermediates,6-Bromo-2-Chloro-8-Cyclopentyl Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd , https://www.dingminpharma.com
Effect of high water temperature on ultrapure water equipment
Ultrapure water equipment has a certain limit on the water temperature of the influent water, and it can work better in a certain temperature range. So what effect does high temperature have on ultrapure water equipment?
Under the condition of high water temperature, the reverse osmosis membrane of ultrapure water equipment has great influence. Firstly, when the water temperature rises, in some systems with constant flow rate, we will find that the desalination rate of the reverse osmosis membrane system has decreased. This is because the water temperature rises due to the increase in water temperature, and the water flux increases. If the constant flow rate is maintained, the operating pressure required to produce the same flow rate of water will decrease, and the operation pressure will decrease, resulting in a decrease in the salt rejection rate. The regeneration cycle of the device is also shortened at the same time. To maintain the system's desalination rate, constant pressure operation is required, but at this time the water production will increase, and as the temperature rises, the water production will increase. Therefore, under high water temperature conditions, the maintenance of system performance needs to be adjusted according to actual needs.
However, the problem of high water temperature on system maintenance is not only these, but the greater danger comes from microbial contamination. Summer water temperatures are mostly between 15 ° C and 30 ° C, and this temperature is also a suitable condition for most bacterial growth. As the water temperature rises, the bacterial metabolic rate and growth rate increase accordingly.
Once the microorganism enters the RO system, it will grow and grow with the nutrient salt concentrated in the concentrated water section of the RO, and even survive in the water producing section. In a hot water environment, the microorganisms multiply rapidly, and a biofilm layer can be formed on the surface of the RO membrane within a few days, resulting in a rapid increase in the pressure difference between the inlet and outlet of the RO system, a rapid decrease in water production and desalination rate, and product water. Being polluted. Bio-contamination leads to the collapse of the diaphragm of the roll-type component, which is known in the industry as a "telescope" phenomenon. When microbial contamination occurs, it is necessary to take timely measures to chemically clean the system. The recommended cleaning agent 0.1% NaOH solution is cleaned under the cleaning conditions of water temperature <30 ° C, pH: 11-12.
The introduction about the impact of high temperature on ultrapure water equipment is here. I hope to help everyone. After knowing the above effects, try to ensure that the water temperature of the influent water is within a certain range. Do not treat ultrapure water. The device is damaged.