Gene detection technology update and breakthrough breakthrough targeted therapy bottleneck October 18, 2016 Source: Pharmaceutical Economics Color Doppler Ultrasound Scanner "Color Doppler Ultrasound Scanner" is a high-definition black-and-white B-ultrasound plus color Doppler. Its main advantages are: it can quickly and intuitively display the two-dimensional plane distribution of blood flow; it can display the running direction of blood flow; it is beneficial to distinguish between arteries and veins; it is beneficial to identify vascular disease and non-vascular disease; it is beneficial to understand the nature of blood flow ; It is convenient to understand the phase and speed of blood flow; it can reliably detect shunt and regurgitation; it can quantitatively analyze the origin, width, length and area of blood flow. These ultrasound manifestations and parameters play a very important auxiliary role in the diagnosis of clinical diseases. Color Doppler Ultrasound Scanner,Color Doppler Scanner,Color Doppler Ultrasonic,Laptop Ultrasonic Scanner Mianyang United Ultrasound Electronics Co., Ltd , https://www.uniultrasonic.com
Gene detection technology update and breakthrough breakthrough targeted therapy bottleneck
Gene detection technology update and breakthrough breakthrough targeted therapy bottleneck
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Recently, at the 2016 Annual Meeting of the Chinese Society of Clinical Oncology, Roche Diagnostics held a conference to introduce a new technology from Roche Diagnostics in detecting lung cancer targets (EGFR and ALK). Achieving concomitant diagnosis through low-cost and high-efficiency means, and classifying lung cancer patients through concomitant diagnosis, thereby implementing safer and more effective targeted therapy is a typical example of precision medicine. Among them, Roche diagnosis cobas EGFR gene mutation detection is a companion diagnostic reagent used in many international large-scale clinical studies.
Professor Cui Tongjian, director of the Department of Oncology, Fujian Provincial Hospital, said frankly: "For EGFR mutations, any method for detecting DNA mutations in the clinic can be detected, but factors such as sample quality, amplification contamination, interpretation errors, operational errors, and DNA quality may affect EGFR. The accuracy of the mutation test results."
At present, accurate detection results play a decisive role in the screening of patients with NSCLC targeted therapy. At present, fluorescence in situ hybridization (FISH) detection is known as the "gold standard" for the determination of ALK fusion genes, but its requirements for manipulation and interpretation techniques are very high, and complete histomorphological structures cannot be obtained under dark vision. At the same time, FISH has a problem of excessive cost, which cannot be applied to large-scale screening and diagnosis of lung cancer patients in China at this stage.
According to Luo Qi, Regional Manager of In Vitro Diagnostics, Roche Diagnostics China Molecular Diagnostics Solution: "Roche Diagnostics VENTANA ALK Immunohistochemistry (IHC) testing for patients and laboratories with its fully automated operating system and high sensitivity and specificity Professionals provide an efficient, standard and economical method for assessing ALK protein expression, achieving high consistency with FISH results, with a repeatability of 99.23%. The test is the only one certified in the European Union. Identification of in vitro diagnostic immunohistochemistry for patients treated with crizotinib."
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