Release date: 2016-04-07 -- Recently, a study published in the international journal Nature Genetics , scientists from the Gladstone Institutes developed a new tool to analyze DNA "dark matter" in detail. In the article, the researchers observed specific fragments of these non-coding DNAs called enhancers. The enhancer plays the role of the gene expression "instruction", which can "dictate" the time and place when the gene is opened for expression. Researcher Dr. Katherine Pollard pointed out that genetic mutations associated with many diseases occur in enhancers, which makes the study of enhancers the focus of future research. Before that, we also conducted a lot of research to reveal enhancements. How do children look for distant genes that they can work with. Scientists originally thought that enhancers mainly affect the expression of genes in their vicinity. However, this study shows that in a DNA strand, enhancers can affect the expression of genes from millions of bases away, that is, skip nearby gene pairs. The expression of the distal gene has an effect; when the enhancer is farther away from the affected gene, it forms a three-dimensional circular structure, just like the "bow"-like structure in the genome. Using machine learning technology, the researchers analyzed database information for hundreds of different cell types in order to find patterns of gene and enhancer interactions in the genome. The researchers found that many Patterns present in the circular structure can link enhancers to genes, and this pattern can also accurately predict whether gene and enhancer interactions will occur 85% of the time. Dr. Sean Whalen said that it is worth noting that we can predict complex three-dimensional interaction patterns from relatively simple data, and no one has clearly revealed the key information in the three-dimensional ring structure, and we are surprised to find this information. It is essential to study the role of non-coding DNA. Experiments in the laboratory to identify patterns of interaction between genes and enhancers can cost millions of dollars and a lot of time, while newer computer methods are cheap and can be used as a time-saving method to identify genes in genes. The way the child works. This new tool can help reveal the mechanism by which DNA loops form and how the loops break in disease. Current researchers can accurately predict the gene targets of enhancers, and this can be used to mutate enhancers. Targeting genes are linked, and this will provide ideas and new insights into understanding the mechanisms by which disease occurs and on the development of novel disease-specific therapies. Source: Bio Valley Tissue Box,Napkins Plastic Box,Car Visor Tissue Box,Pu Leather Car Box YIWU CHUANGCHENG IMPORT&EXPORT CO.,LTD , https://www.tradingsix.com
Nat Genet: New tools for the full analysis of DNA "dark matter"