Release date: 2016-01-12 At the beginning of the 20th century, German scientist Paul Ehrlich came up with the idea of ​​transporting drugs directly to specific targets, which is different from the traditional means by which blood slowly delivers the drug to the lesion. This way more drugs can go faster where they should go, with much less side effects. He called the drug "magic bullet." Ultrasound works because it is a non-invasive treatment and it can focus on specific targets, such as malignant tumors. It not only allows the drug-packed drug to release the drug, but also enhances the permeability of the cell membrane and allows the drug to penetrate deeper into the lesion. Next, Wang and Esener will further develop this ballistic tool to transport a variety of drugs or even to transport different drugs at the same time. It is also possible that such nanocannons are more useful than vaccinations. Source: Omelette Pumpkin Cubes For Canned,Dried Pumpkin Cube,Air Dried Pumpkin,Dpumpkin Cubes Dried Shanghai Sinospices Sourcing Ltd , https://www.garlicall.com
Nanophysical engineers Joseph Wang and Sadik Esener of the University of San Diego used the concept of the magic bullet to design a mini cannon that uses ultrasound to deliver small, drug-containing bullets directly to the body's lesions. Their research was published on the ACS Nano.
We usually associate ultrasound with medical imaging applications, but in fact it can do a variety of treatments. For example, its high-frequency sound waves can loosen the teeth and plaques in the hemostasis (especially tiny blood vessels in vital organs). It also has a great effect on transporting the drug directly to the lesion. 
Wang and Esener first built a miniature cannon (only 5 microns, about the same thickness as the spider silk). They then created a pore-like pore on the membrane, followed by spraying graphene oxide to form a first protective layer covering the pores, and the second protective layer was gold.
They then mounted a 1 micron nano-bomb (similar in size to the HIV virus) on the cannon, made from silica and a liquid gel. The gel also contains perfluorocarbon (PFC) and acts as a fuel. After the PFC is bombarded by the ultrasonic pulse, it will evaporate, and the small bubbles generated in the process will spread rapidly. It is this rapid spread that allows nanocannons to shoot nano-bullets. Without the PFC, the nano cannon was dumb.
Scientists at the University of San Diego successfully sent their nano-bombs to artificial tissue and found that these nanocannons penetrated deeper into the tissue, as they expected. 
Http://gizmodo.com/scientists-build-tiny-microcannons-that-fire-drug-fille-1751172846
Small cannon that can launch drugs into the lesion
The medical community has been dreaming of an ideal transportation system that allows drugs to reach where the body needs them most. Nanoscientists at the University of San Diego have now come up with a novel way to do this: use small cannons to transport drugs to the target.