Analysis of the causes of cracks in tablet presses

When the tablet is pushed out in the die hole, it falls off. It refers to the split. Why is the split, mostly because the fine powder in the particle is too much? When there is air in the particle during compression, the speed is faster when compressed, and the die hole is punched. The gap is small. When the air is compressed, it is not removed from the particles. It is enclosed in the sheet. When there is no pressure, the air will expand and this will cause the split.

According to the above situation, we should first make the fine powder in the granules into a pre-pressing device, so that the air may escape. However, many cases cannot be explained. In the case of relatively high pressure, lobes will occur. When the pressure is reduced, the pressure can be prevented. If the particles are too dry, cleavage will occur, so the water content also plays a key role. . The reason for the lobes is that the compression behavior of the granules is not good, the elasticity of the granules is relatively strong, the elasticity of the pressed tablets is relatively high, and the unevenness of the pressure is also caused.

When the single-press tablet press presses the tablet, the pressure on the tablet is relatively large. When the rotary tablet press presses the tablet, the upper and lower pressure of the tablet is relatively large, and the pressure is related to the elastic recovery rate of the tablet. The elastic recovery rate of the upper and lower surfaces of the tablet is relatively high, and the upper surface of the tablet is first removed from the die hole so that it is split first. Scientific design prescription can prevent the phenomenon of splitting, how to increase the plasticity of the excipients, the formability of the particles, and the addition of compressible starch in the process can solve the above problems. During the pressing process, the possibility of cracking is small, the recovery rate is also small, the compression time is increased, and the plasticity is also increased. This prevents the phenomenon of cracks. The amount of water in the particles can be shaped into particles. Plasticity improves the distribution of pressure and also prevents the phenomenon of splits. It is also possible to add a good amount of lubricant to change the pressure distribution and prevent cracking.

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