Chinese scientists found that early liver cancer can be found in blood biopsy of hepatitis B virus carriers

Chinese scientists found that early liver cancer can be found in blood biopsy of hepatitis B virus carriers

Author: Tian Xiao Air Date: 2019-03-12

Recently, Chinese scientists have developed a technique for early screening of liver cancer by detecting cell free DNA mutations and protein markers in the blood, and early liver cancer can be found from asymptomatic hepatitis B virus carriers. After rigorous clinical validation, this technology is expected to establish a more convenient, non-invasive, standardized early screening program for liver cancer. The research results were published online on the 12th Beijing time by the internationally authoritative academic journal "Journal of the American Academy of Sciences".
The research results were completed by the National Cancer Center/Chinese Academy of Medical Sciences Cancer Hospital team and the Pan-Genetic Gene Company. Wang Sizhen, one of the authors of the paper and CEO of the Panzo Gene Company, said that this technique can detect early liver cancer less than 3 cm in this study. The researchers obtained peripheral blood samples from the peripheral blood to obtain information on cell-free DNA mutations and protein markers, and screened 343 hepatitis B virus carriers with normal alpha-fetoprotein and B-ultrasound detection results, and detected 24 positive cases, and During the follow-up period of 6 to 8 months, 4 of them were found to have liver cancer. The remaining 307 patients were found to have no liver cancer during the follow-up period.
“Clinical early screening is extremely challenging for the design of scientific experiments and their research techniques. This study screened 331 high-risk populations who were asymptomatic, achieving 100% sensitivity and 94% in this cohort. Specificity and a positive predictive value of 17%.” One of the authors, Bohai, the chief scientist of the Panzogen Gene Company, said that the research team is currently using this technology to systematically study the multi-center, larger-scale prospective cohort population. Further optimize screening techniques and methods.
Wang Sizhen said that this technology is expected to be applied to early screening of liver cancer in high-risk groups such as hepatitis B virus carriers, which has high clinical value and social significance.

Source: Xinhua News Agency

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