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Chinese medicine is not "safe and non-toxic" Misuse or cause liver damage
[ China Pharmaceutical Network Health Health ] The ingredients of Xianling Gubao are Epimedium, Dipsacus, Salvia, Zhimu, Buguzhi and Dihuang. It can be used to treat osteoporosis, fractures, osteoarthritis, aseptic necrosis of bone.
(Chinese medicine is not "safe and non-toxic" Misuse or cause liver damage Image source: Baidu pictures)
On December 8, 2016, the State Drug Administration issued an informational report on the “risk of liver damage caused by oral preparations of Xianling Gubaoâ€. In fact, as early as 2013, the National Center for Adverse Drug Reaction Monitoring conducted a safety evaluation of the variety, and then required the company to revise the drug label to clearly indicate the risk of liver damage. Since then, the National Center for Adverse Drug Reaction Monitoring has been closely monitoring the variety. Recent analysis shows that long-term use of drugs, especially elderly patients, may increase the risk of liver damage.
This information notification has once again caused people to pay close attention to the drug-induced liver damage caused by Chinese medicine. According to the traditional concept, people generally think that Chinese medicine is mild and mild, and the adverse reactions are smaller and less than Western medicine. But the author thinks it is necessary to remind everyone: In fact, the misuse of traditional Chinese medicine is very dangerous!
Type of liver damage that may be caused by traditional Chinese medicine
Traditional Chinese medicine has a long history and has a complete theoretical system. Its efficacy has been verified by thousands of years of clinical practice. It can be said that it is widely welcomed by the people. Out of the recognition and trust of traditional Chinese medicine, many people have the idea of ​​"disease cure, disease-free and strong body". The phenomenon of long service and uniforms abounds. With the increasing number of reports of adverse events caused by traditional Chinese medicines, especially drug-induced liver damage, the safety of traditional Chinese medicines has gradually become questionable.
The US FDA's Drug Hepatic Toxicity Steering Committee believes that the drug-induced liver damage caused by Chinese herbal medicine includes liver damage and liver vascular damage. The former is drug-induced hepatitis, which mainly includes acute drug-induced hepatitis, subacute drug-induced hepatitis, and chronic drug-likeness. Hepatitis and the like are generally classified into predictability and unpredictability. Most drug-induced liver damage is unpredictable. The latter mainly includes hepatic venular occlusion, hepatic vein thrombosis, etc. Hepatic vascular disease caused by Chinese herbal medicine is most representative of hepatic venular occlusive disease (HVOD), which has been called hepatic sinusoid in recent years. Obstructive syndrome (SOS).
Traditional Chinese medicine that may cause liver damage
1, botanical
Tripterygium wilfordii, Kunming mountain sea bream, turmeric family Sanqi, Xanthium, Coltsfoot, Senecio, Araceae, Sedum, Sophora, Sophora, Wild Lily , Polygonum multiflorum, Polygonum multiflorum and yellow medicinal herbs, powder anti-self, Mian Ma Guanzhong, Prunella, Chuanxiongzi, bitter skin, horse money, Brucea, poppy shell, bandit and so on.
2, mineral medicine
Cinnabar, realgar, arsenic, light powder, mitopia, patina, etc.
3. Chinese patent medicine
Niuhuang Jiedu Pill, Liushen Pill, Zhuanggu Joint Pill, Keyin Pill, Fufang Qinglan Pill, Tianma Pill, Xuedu Pill, Chafeng Tiaogu Pill, Yuxingcao Injection, Shuanghuanglian Injection, Chuanhuning Injection, Puerarin Injection Liquid, Compound Danshen Injection, Fangfengtongshengsan, Kunming Shanhai Tablets, Guxian Tablets, Yangxueshengfa Capsule, Bushenwufa Capsule, Zheduqing, Xiaokechuan, Zhuanggu Shenjin Capsule, Hyperplasia, Diao Xinxuekang, etc. .
Possible causes of liver damage caused by traditional Chinese medicine
1. Ingredients contained in Chinese herbal medicines or intermediates in the metabolism of the liver cause liver damage, such as warts. This medicine is a dry body of the scorpion animal, which has a long history of medication.蜈蚣 Contains toxic components similar to bee venom, ie histamine-like substances and hemolytic proteins, can cause hemolysis and allergic reactions, causing certain damage to the kidneys and liver, but it is relatively safe in the normal dose range and short-term use.