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China has made new progress in the study of the pathogenic effect of Ebola virus glycoprotein
Medical Network October 17 The Ebola virus is one of the most deadly viruses known to humans, and its pathogenesis is still unclear. The research team of the Wuhan Institute of Virology of the Chinese Academy of Sciences systematically studied the pathogenic effects of Ebola virus envelope glycoprotein expression in cells and mouse models by constructing a series of adenoviral gene transfer vectors.
According to Wang Hualin, a researcher at the Wuhan Institute of Virology, Chinese Academy of Sciences, the Ebola virus encodes multiple forms of glycoproteins, but previous speculations about the potential pathogenic effects of glycoproteins were based only on preliminary studies of cell or tissue culture levels. The relevant pathogenic effects are still lacking direct evidence of in vivo levels. In addition, as a biosafety level 4 virus, the research on the pathogenesis of Ebola virus has been significantly limited by specific experimental conditions such as high-level biosafety laboratories.
In the latest study, Wang Hualin's research team successfully constructed a series of adenoviral gene transfer vectors, and systematically studied Ebola virus under the experimental conditions of biosafety secondary laboratory using adenovirus gene transfer technology. The pathogenic effect of glycoproteins.
Acute inflammation and tissue damage caused by glycoprotein expression suggest that this protein may play an important role in the pathogenesis of Ebola, providing important clues for the pathogenesis of Ebola virus. In addition, the study provides an important and convenient experimental model for further revealing the pathogenic effects of molecular pathogenic factors such as glycoproteins and their molecular mechanisms, and this model may be equally useful for the development of these virulence factors. Specific interventions or treatments.
This means new progress in the study of the pathogenic effects of Ebola virus glycoproteins and their experimental models in China. Some of the results were recently published online in the international authoritative journal Protein and Cell.
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