Chinese scientists develop new pathogen antigenic computing platform

Release date: 2018-05-09

New infectious diseases pose a serious threat to human health and endanger national economic construction and social stability. How to effectively prevent new infectious diseases from spreading among susceptible populations is a major challenge facing humanity. Fudan University disclosed that the Shanghai Public Health Clinical Center, Professor Xu Jianqing from Fudan University Biomedical Research Institute and Professor Cao Zhiwei from the College of Life Science and Technology of Tongji University have jointly developed a new pathogen antigen computing platform.

It is reported that the use of vaccines to prevent infectious diseases is the most effective and economical means, but the traditional vaccine research and development methods are large and time-consuming, which poses serious challenges to timely prevent the spread of new infectious diseases. The research team said that how to use existing vaccines or design broad-spectrum antiviral vaccines to prevent new infectious diseases is the most worthwhile exploration. The core technical problems and challenges are how to quickly screen or design to target similar viruses. Vaccine immunogens with cross-protection of different viruses.

The researchers designed a spatial immunological epitope comparison tool CE-BLAST to efficiently calculate the antigenic distance between different pathogens. Compared with previous calculation methods, the biggest advantage of CE-BLAST is that it can build the model without using experimental data as training. For some new pathogens that still lack experimental data and new outbreaks of infectious diseases (such as Card virus) is especially critical.

The research results have recently been published online in Nature Communication on CE-BLAST, a new platform for calculating the antigenic similarity of pathogens in emerging infectious diseases.

According to reports, the researchers in the virus subtypes between different strains (influenza A H3N2 subtype), between different subtypes of the virus (dengue virus different serotypes), cross-virus (viral virus dengue virus and village The card virus) verified the effectiveness of the method in three levels.

The researchers also used CE-BLAST to construct a broad-spectrum vaccine against different strains of influenza A virus H3N2 subtype, and obtained a good spectrum of protection in animal experiments. Studies have shown that this method is expected to design a new vaccine with cross-protection against new viruses.

According to reports, it is interesting to note that this method calculates a highly similar antibody epitope between Zika and dengue virus. The existing dengue vaccine has the potential to cross-check the Zika virus, and this prediction has been tested in other laboratories in the field. The animal research institute confirmed.

Source: China News Network

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