Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (CGMP) - specific phosphodiesterase 5 (PDE5) and an oral drug for the treatment of ED. The physiological mechanism of normal penile erection involves the release of nitric oxide (no) during sexual stimulation. Nitric oxide activates guanylate cyclase in the smooth muscle cells of the corpus cavernosum, which leads to the increase of cGMP level, resulting in the relaxation of the smooth muscle in the corpus cavernosum, the expansion of the cavernous sinus and the inflow of blood. Erectile dysfunction is mainly due to the dysfunction of smooth muscle relaxation of corpus cavernosum. Sildenafil has no direct relaxation effect on human sponges in vitro, but can enhance the effect of nitric oxide by inhibiting the decomposition of cGMP by PDE5 in sponges. Sildenafil can inhibit PDE5, increase cGMP level, relax smooth muscle of corpus cavernosum and let blood flow into corpus cavernosum. Studies have shown that erectile response increases with the increase of dose and plasma concentration, and the efficacy can last for 4 hours (but is weaker than that at 2 hours). Sarms Capsules,Sildenafil Capsules,Healthcare Capsules,Herbal Capsules Xi'an Tian Guangyuan Biotech Co., Ltd. , https://www.tgybiotech.com
Technical Details of sex doll:
Full body silicone sex doll with  skeleton (158cm)
Skin  Material
TPE
InsideÂ
TPE with metal skeleton
Net Weight
60 lbs / 30KG
Height
60.2" / 158cm
Bust
38.6" /98cm
Waist
20.5" / 52cm
Hip
33.8" / 86cmÂ
Vagina depth
7" / 18cm
Vagina
Built in / RemovableÂ
MOQ
1 pieces
Customized
Available
Delivery Detail
Shipped in 1-3 days after payment
Certification
 CE, ROHS, MSDS ,EN71, 6P
Additional gift
1*clothes   1* hairpiece   1*comb   1* vagina cleaning deviceÂ
1* condom  1* blanket
We supply unique design and superior quality dolls for you.
Here you can buy your favorite doll and you get perfect sex doll
1).These love dolls are made of high-quality soft rubbery material that feels like real skin, adjustable hands, a removable head and genitals.
2)Perfect oriental female physiological characteristics.
3)Metal skeleton, maintain long-term deformation.
4)Limb joints move freely, placed at random satisfactory shape
High simulation, the closest simulation of real touch dolls.
Â
Since humans are sexual creatures,we help people explore their sexuality to the fullest extent with top qulity sex toys sex girl dolls &  100% solid medical silicone sex dolls, NOT inflatable doll.
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Features :
1.No-toxic, no smell, 100% soft and real touch
2.Can do oral sex, breast sex, vagina sex, and anal sex
3.can show any pose with flexible skeleton during love
4.TPE Full medical silicon made, stainless steel skeleton inside
Â
We promises: You will get 100% same as below picture dolls.
Technical Details of sex doll:
Full body silicone sex doll with  skeleton (158cm)
Skin  Material
TPE
InsideÂ
TPE with metal skeleton
Net Weight
60 lbs / 30KG
Height
60.2" / 158cm
Bust
38.6" /98cm
Waist
20.5" / 52cm
Hip
33.8" / 86cmÂ
Vagina depth
7" / 18cm
Vagina
Built in / RemovableÂ
MOQ
1 pieces
Customized
Available
Delivery Detail
Shipped in 1-3 days after payment
Certification
 CE, ROHS, MSDS ,EN71, 6P
Additional gift
1*clothes   1* hairpiece   1*comb   1* vagina cleaning deviceÂ
1* condom  1* blanket
We supply unique design and superior quality dolls for you.
Here you can buy your favorite doll and you get perfect sex doll
1).These love dolls are made of high-quality soft rubbery material that feels like real skin, adjustable hands, a removable head and genitals.
2)Perfect oriental female physiological characteristics.
3)Metal skeleton, maintain long-term deformation.
4)Limb joints move freely, placed at random satisfactory shape
High simulation, the closest simulation of real touch dolls.
Â
Since humans are sexual creatures,we help people explore their sexuality to the fullest extent with top qulity sex toys sex girl dolls &  100% solid medical silicone sex dolls, NOT inflatable doll.
Â
Features :
1.No-toxic, no smell, 100% soft and real touch
2.Can do oral sex, breast sex, vagina sex, and anal sex
3.can show any pose with flexible skeleton during love
4.TPE Full medical silicon made, stainless steel skeleton inside
Â
Real Silicone Sex Doll 158cm Full Size Lifelike TPE Sex Robot Anime Doll
Model NO.: 158+185-Jm19
Usematerial: 100% TPE with Metal Skeleton
Sex Way: Oral Sex,Vaginal Sex, Anal Sex,Breast
Advantage: Safe,Soft,Smooth,Real Feel,No Peculiar Smell,Top Q
Age: 18-80
Grade: Top Quality
Skin Color: (Brown ,Nature ,White)Three Optional
Size: 65-175cm
Certification: Ce,RoHS,MSDS,En71
Hairstyle: Can Choose
Clean: Easy to Clean
Trademark: WMDOLL
Transport Package: 155cm X 45cm X 35cm
Specification: 158CM
HS Code: 96180000
Model NO.: 158+185-Jm19
Usematerial: 100% TPE with Metal Skeleton
Sex Way: Oral Sex,Vaginal Sex, Anal Sex,Breast
Advantage: Safe,Soft,Smooth,Real Feel,No Peculiar Smell,Top Q
Age: 18-80
Grade: Top Quality
Skin Color: (Brown ,Nature ,White)Three Optional
Size: 65-175cm
Certification: Ce,RoHS,MSDS,En71
Hairstyle: Can Choose
Clean: Easy to Clean
Trademark: WMDOLL
Transport Package: 155cm X 45cm X 35cm
Specification: 158CM
HS Code: 96180000
We promises: You will get 100% same as below picture dolls.Â
If  you need  nude or more pictures ,please send us Email
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If  you need  nude or more pictures ,please send us Email