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Recently, a research report published in the international journal Nature Communications, scientists from the European Molecular Biology Laboratory designed a new method that can cheaply manufacture compounds that are important to the pharmaceutical industry - amines. Substance; amines are now a major class of major compounds, which contain a cyclic structure called an aromatic group, which is widely used in the pharmaceutical industry, such as the best-selling drug Abilify, can be determined, Wei and Lidocaine and so on.
Amine compounds carrying an aromatic ring structure are collectively referred to as heteroarylamine compounds, which are widely used in medicinal chemistry research processes, which involve primarily linking amine groups to functional organic molecules. The manufacture of amine compounds requires three steps capable of producing the toxic compound aniline, which is commonly used in the industry for polyurethanes, while chemists also inject hydrogen into aniline to produce arylamine compounds.
In this study, the researcher XileHu and colleagues developed a new method for the preparation of arylamines. This method does not require the first step of aniline synthesis. Instead of catalyzing with iron, they can combine amines with organic compounds. Linked to create a functional compound. Researchers have developed new methods to bypass the aniline synthesis step, and with this new method researchers can create arylamine compounds that are highly resistant to functional groups.
Researchers say that we can use amine compounds made by conventional aniline synthesis in a range of chemical applications. In the conventional aniline synthesis, some functional groups need to be protected, which means The arylamines produced by the new method may be safer.
Finally, the researchers say that this new method can help chemists to make amines in a cheaper way, and that this method may be a new alternative to current amination methods, which is cheaper for later scientists. The new way to make new drugs for the treatment of a variety of diseases will bring revolutionary changes.
New methods can replace current amination methods to reduce the cost of pharmaceutical companies
[China Pharmaceutical Network Technology News] It is reported that European scientists have invented a new method that can cheaply manufacture amines, which are very important to the pharmaceutical industry. This new approach can help chemists make amines in a cheaper way, and this approach may be a new alternative to current amination methods.