High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8

High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8

Model NO.: Wz4002
Mf: C25h27cln6o3
MW: 494.18
CAS: 1213269-23-8
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
Model NO.: Wz4002
Mf: C25h27cln6o3
MW: 494.18
CAS: 1213269-23-8
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
 WZ4002 Basic Info.
Other Names:WZ4002;N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;WZ4002(HBr);N-{3-[(5-Chloro-2-{[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino}-4-pyriMidinyl)oxy]phenyl}acrylaMide;N-[3-[5-chloro-2-[2-Methoxy-4-(4-Methylpiperazin-1-yl)anilino]pyriMidin-4-yl]oxyphenyl]prop-2-enaMide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide WZ 4002;WZ 4002 N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
Model No.: ATC-139
CAS No.: 1213269-23-8
MF: C25H27ClN6O3
MW:494.18
Appearance: White or Nearly White Crystalline Powder
Purity: 99%+
Product Specifications: Pharmaceutical Grade 
Standard: Qualified
Packing: Aluminium Foil Bag or as Required    


Description  
WZ4002 is a novel, mutant-selective inhibitor of EGFR for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM. 
WZ4002 inhibits other EGFR genotypes E746_A750 and E746_A750/T790M with IC50 of 2 and 6 nM. Besides, WZ4002 suppresses widetype ERBB2 with an IC50 of 32 nM. WZ4002 inhibits EGFR, AKT and ERK1/2 phosphorylation in NSCLC cell lines and WZ4002 prevents of EGFR phosphorylation in NIH-3T3 cells expressing different EGFR T790M mutant alleles. For WZ4002, kinases that exhibited greater than 95% inhibition relative to the DMSO control at 10 μM are selected for measurement of their dissociation constants. WZ4002, which possesses an ortho-methoxy group at the C2-aniline substituent, is more selective for EGFR compared to WZ3146. WZ4002 is 100-fold less effective at inhibiting phosphorylation of WT EGFR compared to the quinazoline inhibitors. Similarly, WZ4002 prevents EGFR kinase activity of recombinant L858R/T790M protein more potently than of WT EGFR, while the opposite is observed with HKI-272 . In addition, the phosphorylated EGFR of Src TKI-resistant H1975 cells, as well as HCC827 cells, is completely suppressed by the third generation EGFR TKI, WZ4002.
 
Application
Treatment with WZ4002 completely inhibited the growth of PC-9/Vec tumors, whereas treatment with E7050 did not (Fig. A). Treatment with either agent a lone slightly suppressed the growth of PC- 9/HGF#5 t umor s ( Fig. B). Importantly, the combination of WZ4002 and E7050 reduced the size of PC-9/HGF#5 tumors(Fig.B).These results suggest that HGF can induce resistance to WZ4002 in vivo and that this resistance can be overcome by E7050. In the second model, the growth of tumors induced by H1975 cells, which carry a T790M second mutation, was inhibited by WZ4002 (Fig. C), In the third model, in which resistance was induced by Met amplification, monotherapy with either WZ4002 or E7050 partially inhibited the growth of HCC827ER tumors(Fig. D) 

Real figure of  WZ4002 :

High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8

High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8

 WZ4002  packing :
High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8

 
Wuhan Deme chem Biotechnology Co., Ltd is a new and high-tech enterprise. 
The main business is research and development, production, sales for Steroid, Active ingredient and Pharmaceutical .
   


 WZ4002  manufacturer production pictures:
High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8


The list of cortical hormone drugs is as follows:
Name standard CAS
Prednisolon Acetate Usp32 /ep6 52-21-1
Prednisolon Base Bp2010/Usp32/Ep7 50-24-8
Prednison Usp32 1953/3/2
Prednison Acetate Cp2005 125-10-0
Betamethasone Base Ep6 378-44-9
Betamethaasone Usp32 5593-20-4
Dipropionate    
     
Clobetasol Propionate Usp34 25122-46-7
Cortisone Acetate enterprise standard 1950/4/4
     
Dexamethasone Sodium Phosphate EP6 2392-39-4
     
Fluocinolone Acetonide Usp32 67-73-2
Fluocinonide Usp32/CP 356-12-7
Hydrocortisone Ep7 50-23-7
     
Hydrocortisone Acetate Ep7 1950/3/3
Dexamethasone Acetate EP6 1177-87-3
Triamcinol0ne acetonide acetate enterprise standard 3870/7/3
Triamcinol0n Acetonide BP/USP/EP 76-25-5
Triamcinol0ne Base BP/USP/EP 124-94-7
Halcinonide Cp2005 3093-35-4
16α-Hydroxy-Prednisolone enterprise standard 13951-70-7


Reason to choose us 

.Guarantee the quality of products ,our Pharmaceutical Intermediate purity≥99% .

.Variety diversification & Adequate stock make sure we could meet your require

.Professional service and rich experience ,we also could give you some advise about 
please feel free to contact us if you have any question.

Payment Term:T/T  , Moneygram , Western Union.

Delivery

1. Sent out in 24hours once payment comfirm.

2. Professional agent make sure our ship fastly and safety

3.Offer your tracking number to you once we get it ,in order to facilitate you track the express
   WZ4002 Basic Info.
Other Names:WZ4002;N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;WZ4002(HBr);N-{3-[(5-Chloro-2-{[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino}-4-pyriMidinyl)oxy]phenyl}acrylaMide;N-[3-[5-chloro-2-[2-Methoxy-4-(4-Methylpiperazin-1-yl)anilino]pyriMidin-4-yl]oxyphenyl]prop-2-enaMide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide WZ 4002;WZ 4002 N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
Model No.: ATC-139
CAS No.: 1213269-23-8
MF: C25H27ClN6O3
MW:494.18
Appearance: White or Nearly White Crystalline Powder
Purity: 99%+
Product Specifications: Pharmaceutical Grade 
Standard: Qualified
Packing: Aluminium Foil Bag or as Required    


Description  
WZ4002 is a novel, mutant-selective inhibitor of EGFR for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM. 
WZ4002 inhibits other EGFR genotypes E746_A750 and E746_A750/T790M with IC50 of 2 and 6 nM. Besides, WZ4002 suppresses widetype ERBB2 with an IC50 of 32 nM. WZ4002 inhibits EGFR, AKT and ERK1/2 phosphorylation in NSCLC cell lines and WZ4002 prevents of EGFR phosphorylation in NIH-3T3 cells expressing different EGFR T790M mutant alleles. For WZ4002, kinases that exhibited greater than 95% inhibition relative to the DMSO control at 10 μM are selected for measurement of their dissociation constants. WZ4002, which possesses an ortho-methoxy group at the C2-aniline substituent, is more selective for EGFR compared to WZ3146. WZ4002 is 100-fold less effective at inhibiting phosphorylation of WT EGFR compared to the quinazoline inhibitors. Similarly, WZ4002 prevents EGFR kinase activity of recombinant L858R/T790M protein more potently than of WT EGFR, while the opposite is observed with HKI-272 . In addition, the phosphorylated EGFR of Src TKI-resistant H1975 cells, as well as HCC827 cells, is completely suppressed by the third generation EGFR TKI, WZ4002.
 
Application
Treatment with WZ4002 completely inhibited the growth of PC-9/Vec tumors, whereas treatment with E7050 did not (Fig. A). Treatment with either agent a lone slightly suppressed the growth of PC- 9/HGF#5 t umor s ( Fig. B). Importantly, the combination of WZ4002 and E7050 reduced the size of PC-9/HGF#5 tumors(Fig.B).These results suggest that HGF can induce resistance to WZ4002 in vivo and that this resistance can be overcome by E7050. In the second model, the growth of tumors induced by H1975 cells, which carry a T790M second mutation, was inhibited by WZ4002 (Fig. C), In the third model, in which resistance was induced by Met amplification, monotherapy with either WZ4002 or E7050 partially inhibited the growth of HCC827ER tumors(Fig. D) 

Real figure of  WZ4002 :

High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8

High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8

 WZ4002  packing :
High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8

 
Wuhan Deme chem Biotechnology Co., Ltd is a new and high-tech enterprise. 
The main business is research and development, production, sales for Steroid, Active ingredient and Pharmaceutical .
   


 WZ4002  manufacturer production pictures:
High Purity Above 99.5% Wz4002 Powder for Nhibitor of Egfr CAS: 1213269-23-8


The list of cortical hormone drugs is as follows:
Name standard CAS
Prednisolon Acetate Usp32 /ep6 52-21-1
Prednisolon Base Bp2010/Usp32/Ep7 50-24-8
Prednison Usp32 1953/3/2
Prednison Acetate Cp2005 125-10-0
Betamethasone Base Ep6 378-44-9
Betamethaasone Usp32 5593-20-4
Dipropionate    
     
Clobetasol Propionate Usp34 25122-46-7
Cortisone Acetate enterprise standard 1950/4/4
     
Dexamethasone Sodium Phosphate EP6 2392-39-4
     
Fluocinolone Acetonide Usp32 67-73-2
Fluocinonide Usp32/CP 356-12-7
Hydrocortisone Ep7 50-23-7
     
Hydrocortisone Acetate Ep7 1950/3/3
Dexamethasone Acetate EP6 1177-87-3
Triamcinol0ne acetonide acetate enterprise standard 3870/7/3
Triamcinol0n Acetonide BP/USP/EP 76-25-5
Triamcinol0ne Base BP/USP/EP 124-94-7
Halcinonide Cp2005 3093-35-4
16α-Hydroxy-Prednisolone enterprise standard 13951-70-7


Reason to choose us 

.Guarantee the quality of products ,our Pharmaceutical Intermediate purity≥99% .

.Variety diversification & Adequate stock make sure we could meet your require

.Professional service and rich experience ,we also could give you some advise about 
please feel free to contact us if you have any question.

Payment Term:T/T  , Moneygram , Western Union.

Delivery

1. Sent out in 24hours once payment comfirm.

2. Professional agent make sure our ship fastly and safety

3.Offer your tracking number to you once we get it ,in order to facilitate you track the express
 

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